Yes, using wallpaper to create a focal point in a room is a popular design technique. By choosing a bold pattern or an accent wall to apply the wallpaper, you can create a visually striking feature that draws the eye and anchors the room. You can choose from a variety of patterns, colors, and textures to complement your existing decor and create a cohesive look. Just be sure to balance the wallpapered focal point with other elements in the room to avoid an overly busy or cluttered appearance.